标准编号：ISO 17735:2019
中文名称：工作场所空气 用1-（9-蒽甲基）哌嗪（MAP）试剂和液相色谱法测定空气中异氰酸酯基团总数
英文名称：Workplace atmospheres — Determination of total isocyanate groups in air using 1-(9-anthracenylmethyl)piperazine (MAP) reagent and liquid chromatography
发布日期：2019-04
标准范围
This document specifies a method for the sampling and analysis of airborne organic isocyanates in
workplace air.
This document is applicable to a wide range of organic compounds containing isocyanate groups,
including monofunctional isocyanates (e.g. phenyl isocyanate), diisocyanate monomers [e.g.
1,6-hexamethylene diisocyanate (HDI), toluene diisocyanate (TDI), 4,4′-diphenylmethane diisocyanate
(MDI), and isophorone diisocyanate (IPDI)], prepolymers (e.g. the biuret and isocyanurate of HDI), as
well as chromatographable intermediate products formed during production or thermal breakdown of
polyurethane.
In mixed systems of HDI and IPDI products, it is impossible to identify and quantify low levels of IPDI
monomer using this document, due to coelution of IPDI monomer with HDI-uretidinedione.
It is known that the method underestimates the oligomer in MDI-based products. Total isocyanate
group (NCO) is underestimated in MDI-based products by about 35 % as compared to dibutylamine
titration.
The method has been successfully modified to be used with LC-MS-MS for TDI monomer using an
isocratic 70 % acetonitrile/30 % 10 mM ammonium formate mobile phase.
The useful range of the method, expressed in moles of isocyanate group per species per sample, is
approximately 1 × 10−10 to 2 × 10−7. The instrumental detection limit for the monomers using both
ultraviolet (UV) detection and fluorescence (FL) detection is about 2 ng monomer per sample. The
useful limit of detection for the method using reagent impregnated filters is about 10 ng to 20 ng
monomer per sample for both UV and FL detection. For a 15 l sample, this corresponds to 0,7 µg/m−3 to
1,4 µg/m−3 . For impinger samples, which require solid phase extraction, experience has shown that the
useful limit of detection is about 30 ng to 80 ng monomer per sample.
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